Development of a new chemical introduction process for hours living radioisotope and it's application for PET imaging agent

A new chemical introduction process of fluorine-18, 18F was developed using solid phase synthesis technique, instead of a conventional liquid phase synthesis. Separation for a plenty of non-reaction compound was difficult in the liquid phase synthesis technique. Precursor compound reacted on the surface of solid phase (beads). Labeled compound with 18F could be separated from the solid surface by reaction of fluoride reagent. A fundamental fluoric reaction was developed with the solid phase process. Sulfonyl chloride, polymer-bound 1 was used as a solid phase carrier of the precursor. The 18F-FDG, which are replaced a hydroxyl group in D-glucose with 18F, were used most frequently as a cancer marker in positron computed tomography (PET). Synthesis of the 18F-FDG was investigated by the solid phase technique. (M. Suetake)