Published October 17, 1984
| Version v1
Journal article
Mathematical modelling of DNA replication in UV-irradiated bacteria
- 1. Institut Rudjer Boskovic, Zagreb (Yugoslavia)
Description
A mathematical model of semi-conservative DNA replication in UV-irradiated bacteria has been developed, based on the Poisson distribution of the dimers through bacterial population, uniform distribution of dimers in the chromosome, and the assumption that a pyrimidine dimer is a complete block to DNA synthesis. The model is numerically evaluated by digital simulation, using the Monte Carlo method. Compared with experimental work on DNA synthesis in UV-irradiated bacteria, the results strongly suggest that the pyrimidine dimer is not an absolute block to DNA synthesis in the absence of repair. (author)
Additional details
Publishing Information
- Journal Title
- Stud. Biophys.
- Journal Volume
- 102
- Journal Issue
- 2
- Series
- Stud. Biophys.
- Journal Page Range
- 97-106
- ISSN
- 0081-6337
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- German Democratic Republic
- INIS RN
- 16023870
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- DIMERS; DNA REPLICATION; ESCHERICHIA COLI; MATHEMATICAL MODELS; MONTE CARLO METHOD; MUTANTS; PYRIMIDINES; TIME DEPENDENCE; ULTRAVIOLET RADIATION
- Descriptors DEC
- AZINES; BACTERIA; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; MICROORGANISMS; NUCLEIC ACID REPLICATION; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATIONS