Published March 2018
| Version v1
Journal article
Celastrol pretreatment attenuates rat myocardial ischemia/ reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway
- 1. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (United States)
- 2. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei (China)
Description
Celastrol pretreatment has been shown to protect against myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism is poorly understood. This study aimed to investigate the cardioprotective effects of celastrol pretreatment on I/R injury and to further explore whether its mechanism of action was associated with the inhibition of high mobility group box 1 protein (HMGB1) expression via the phosphoinositide 3-kinase (PI3K)/Akt pathway.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.bbrc.2018.02.121Additional details
Identifiers
- DOI
- 10.1016/j.bbrc.2018.02.121;
- PII
- S0006291X18303528;
Publishing Information
- Journal Title
- Biochemical and Biophysical Research Communications
- Journal Volume
- 497
- Journal Issue
- 3
- Journal Page Range
- p. 843-849
- ISSN
- 0006-291X
- CODEN
- BBRCA9
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 53054527
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- INJURIES; ISCHEMIA; PHOSPHOTRANSFERASES; RATS
- Descriptors DEC
- ANEMIAS; ANIMALS; CARDIOVASCULAR DISEASES; DISEASES; ENZYMES; HEMIC DISEASES; MAMMALS; ORGANIC COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; PROTEINS; RODENTS; SYMPTOMS; TRANSFERASES; VASCULAR DISEASES; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2018 Published by Elsevier Inc.