Published May 2003 | Version v1
Journal article Metadata-only

In-vivo behavior of tin-radiopharmaceuticals

Creators

  • 1. Chinese Academy of Engineering Physics, Mianyang (China). Inst. of Nuclear Physics and Chemistry

Description

Tin is an essential ingredient of most technetium-99m radiopharmaceuticals but its in-vivo distribution and long-term fate are not well understood. This work describes distribution in mice of several tin-117m labeled compounds. The results indicate that stannic-HEDTMP appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake, and its binding to bone is higher than that of tin-117m-DTPA, which make it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors

Additional details

Publishing Information

Journal Title
Nuclear Science and Techniques
Journal Volume
14
Journal Issue
2
Journal Page Range
p. 127-130
ISSN
1001-8042

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
35033114
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL LOCALIZATION; IN VIVO; NEOPLASMS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RADIOTHERAPY; SCINTISCANNING; SKELETAL DISEASES; SKELETON; TIN 117; TISSUE DISTRIBUTION; UPTAKE
Descriptors DEC
BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DRUGS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MATERIALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY; STABLE ISOTOPES; THERAPY; TIN ISOTOPES