A comparison of anti-tumor effects of high dose rate fractionated and low dose rate continuous irradiation in multicellular spheroids
Creators
- 1. Ibaraki Prefectural Univ. of Health Sciences, Ami (Japan)
Description
In a clinical experience, high dose rate (HDR) fractionated interstitial radiotherapy can be an alternative to traditional low dose rate (LDR) continuous interstitial radiotherapy for head and neck cancers. To investigate biological effect of HDR, compared to LDR, comparisons have been made using spheroids of human squamous carcinoma cells. Both LDR and HDR were delivered by 137Cs at 37degC. Dose rate of LDR was 8 Gy/day and HDR irradiations of fraction size of 4, 5 or 6 Gy were applied twice a day with an interval time of more than 6 hr. We estimated HDR fractionated dose of 31 Gy with 4 Gy/fr to give the same biological effects of 38 Gy by continuous LDR for spheroids. The ratio of HDR/LDR doses to control 50% spheroids was 0.82. (author)
Additional details
Publishing Information
- Journal Title
- Gan No Rinsho
- Journal Volume
- 43
- Journal Issue
- 2
- Journal Page Range
- p. 173-177.
- ISSN
- 0021-4949
- CODEN
- GANRAE
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 28033553
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; CELL KILLING; CESIUM 137; FRACTIONATED IRRADIATION; RADIATION DOSES; SPHEROIDS; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CESIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; IRRADIATION; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES