Published July 1979 | Version v1
Journal article Metadata-only

Effects of gamma radiation and heat on immunogenicity and morphology of Salmonella typhimurium

Creators

  • 1. Escola Superior de Agricultura de Paraguacu Paulista, Sao Paulo (Brazil)
  • 2. Centro de Energia Nuclear na Agricultura, Piracicaba (Brazil)

Description

Results are presented about immunogenicity of vaccines prepared from Salmonella typhimurium suspensions submitted to 0,55 MR and 1,10 MR of gamma radiation and heating at 600C, (60 min) and at 1000C, (3 min) correlated with the cell morphology alterations observed at electron microscopy. The results of mouse-protection tests showed that prepared vaccines with 0,55 MR and with heating at 600C, 60 min were identical and more efficient than the two other treatments. The electronmicrografies also showed one positive correlation between morphological alterations caused by the treatments and the immunogenicities. (Author)

Abstract (Portuguese)

Estudaram-se as imunogenicidades de vacinas preparadas a partir de suspensoes de Salmonella typhimurium submetidas a 0,55 MR e 1,10 MR de radiacao gama e ao aquecimento a 600C por 60 minutos e a 1000C por 3 minutos, relacionando-as com os danos morfologicos das celulas observadas ao microscopio eletronico. Os testes de protecao em camundongos mostraram que as vacinas preparadas com 0,55 MR e aquecimento a 600C por 60 minutos, foram igualmente eficientes e superiores aos dois outros tratamento. Os exames das eletromicrografias mostraram haver correlacao positiva entre as alteracoes morfologicas provocadas pelos tratamentos e as imunogenicidades. (Autor)

Additional details

Additional titles

Original title (Portuguese)
Efeitos da radiacao gama e do calor na imunogenicidade e morfologia da Salmonella typhimurium

Publishing Information

Journal Title
Energ. Nucl. Agric.
Journal Volume
1
Journal Issue
2
Series
Energ. Nucl. Agric.
Journal Page Range
94-101
ISSN
0100-3593

INIS

Country of Publication
Brazil
Country of Input or Organization
Brazil
INIS RN
11565172
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANTIBODY FORMATION; ELECTRON MICROSCOPY; GAMMA RADIATION; MICE; RADIOIMMUNOLOGY; SALMONELLA TYPHIMURIUM; TEMPERATURE DEPENDENCE; THRESHOLD DOSE; ULTRASTRUCTURAL CHANGES; VACCINES
Descriptors DEC
ANIMALS; BACTERIA; ELECTROMAGNETIC RADIATION; IMMUNOLOGY; IONIZING RADIATIONS; MAMMALS; MICROORGANISMS; MICROSCOPY; MORPHOLOGICAL CHANGES; RADIATION DOSES; RADIATIONS; RODENTS; SALMONELLA; VERTEBRATES