Relationship between cord blood IGF-I, IGFBP-3 levels and intrauterine growth retardation (IUGR)
Creators
- 1. Department of Laboratory, The Affiliated Hospital of Medical College, Qingdao Univ., Qingdao (China)
Description
Objective: To study the cord blood insulin-like growth factor-I (IGF-I) and its binding protein-3 (IGFBP-3) levels in neonates with intrauterine growth retardation (IUGR). Methods: Cord serum IGF-I (with RIA) and IGFBP-3 (with IRMA) levels were measured in 22 neonates with IUGR and 64 neonates with appropriate gestational age (AGA). Results: Cord blood IGF-I and IGFBP-3 levels in IUGR neonates were significantly lower than those in AGA neonates (P<0.001). Among the 86 neonates studied in this article, 44 were born pre-term and 42 were born full term. From the data, we could see that the cord blood IGF-I and IGFBP-3 levels in pre-term neonates were significantly lower than those in full-term neonates (P also <0.001). IGF-I and IGFBP-3 levels were mutually positively correlated (P<0.01). Conclusion: Cord blood IGF-I and IGFBP-3 levels were useful indicator of neonates growth. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 21
- Journal Issue
- 1
- Journal Page Range
- p. 8-9
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 41053254
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOLOGICAL INDICATORS; BLOOD SERUM; CORRELATIONS; GROWTH FACTORS; INSULIN; NEONATES; ONTOGENESIS; PROTEINS; RADIOIMMUNOASSAY; UTERUS
- Descriptors DEC
- ANIMALS; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; FEMALE GENITALS; HORMONES; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; MITOGENS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; TRACER TECHNIQUES
Optional Information
- Notes
- 2 tabs., 4 refs.