Radiation-induced micronucleus formation in animal model and DNA damage in human lymphocytes and their prevention by 4-amino-4H-1,2,4-triazole-3-thiole

Protection of biological systems against radiation damage is of paramount importance during accidental and unavoidable exposure to radiation. Several physico-chemical and biological factors collectively contribute to the damage caused by radiation and are, therefore, targets for developing radioprotectors. Chemicals capable of scavenging free radicals, relieving oxidative stress,promoting antioxidant activity and modulating immune response have been some of the radioprotectors extensively investigated with limited success. It has long been known that some of the most effective radioprotective agents are those which contain sulphydryl groups. The aim of the present study was to asses an electron beam radiation induced micronucleus formation in mice and DNA damage in human lymphocytes and protective effect of triazole (100μg/ml) derivative against the radiation induced damage