Published 1976 | Version v1
Report Metadata-only

Therapy of uranium contaminations

Creators

  • 1. Centre de Recherches du Service de Sante des Armees, 92 - Clamart (France). Div. de Radiobiologie Experimentale

Description

Renal risks associated with the use of chelating agent as a treatment for acute uranium contamination were investigated. Rats were given a single intramuscular injection of uranyl nitrate solution. The percentage of renal uptake of uranyl nitrate as a function of the quantity injected was measured. Then the effect of a single DTPA intraperitoneal injection and the effect of a single bicarbonate injection on renal uptake of uranyl nitrate were studied. The preliminary results were as follows: constancy of renal uptake of uranyl nitrate (13 to 20% of the quantity injected); harmlessness of DTPA as a treatment for uranium contamination (DTPA does not increase uranium renal burden); inefficacy of bicarbonates on uranyl renal uptake

Abstract (French)

On a etudie les risques renaux lies a l'utilisation d'un chelateur dans les contaminations aigues par l'uranium. On a contamine des rats par une injection intramusculaire unique d'une solution de nitrate d'uranyle. On a mesure le pourcentage de fixation renale de nitrate d'uranyle en fonction de la quantite injectee. Puis on a etudie l'effet d'une injection intraperitoneale unique de DTPA et l'effet d'une injection unique de bicarbonates sur la fixation renale du nitrate d'uranyle. Les resultats preliminaires sont les suivants: charge renale quasi constante en uranyle en pourcentage de la quantite injectee (13 a 20%); inocuite de l'emploi du DTPA en cas de contamination par l'uranium, (le DTPA n'augmente pas la charge renale en uranium); inefficacite des bicarbonates sur la fixation renale de l'uranyle

Additional details

Additional titles

Original title (French)
Therapeutique des contaminations par l'uranium

Publishing Information

Imprint Title
1976 scientific works
Journal Page Range
p. 149-154.
Report number
CRSSA-RA--1976

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
9414588
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Progress Report
Descriptors DEI
BIOLOGICAL EFFECTS; CARBONATES; DECONTAMINATION; DTPA; INTRAMUSCULAR INJECTION; INTRAPERITONEAL INJECTION; KIDNEYS; RADIONUCLIDE KINETICS; RATS; UPTAKE; URANIUM; URANYL NITRATES
Descriptors DEC
ACTINIDE COMPOUNDS; ACTINIDES; AMINO ACIDS; ANIMALS; BODY; CARBON COMPOUNDS; CARBOXYLIC ACIDS; CHELATING AGENTS; CLEANING; ELEMENTS; INJECTION; INTAKE; KINETICS; MAMMALS; METALS; NITRATES; NITROGEN COMPOUNDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; RODENTS; URANIUM COMPOUNDS; URANYL COMPOUNDS; VERTEBRATES

Optional Information

Notes
Imprint:Travaux scientifiques. Annee 1976.