Agenesis of the corpus callosum with cerebellar vermian hypoplasia in a foal resembling the Dandy-Walker syndrome: pre-mortem diagnosis by clinical evaluation and CT scanning

Dorsal midline dysgenesis of the human brain, a complex pattern of maldevelopment of sulcation and neuronal migration occurring before 74 days gestation, has been recognised for over fifty years. The association (68 per cent) of the so-called Dandy-Walker syndrome (eystic dilataion of the fourth ventricle and hypoplasia of the cerebellum) with other brain malformations is common and often includes agenesis of the corpus callosum (Hart, Malamud and Ellis 1972; Ral et al 1980). this report describes the first pre-mortem identification of such a structural brain anomaly in a Thoroughbred foal