The restorative effect of mouse intestinal RNA on the small intestine of mice of the same strain after γ ray irradiation

Mouse intestinal RNA was injected into the mice of the same strain within 1-3 h after different doses of abdominal or whole body 60Co γ irradiation, so as to explore the initial effective time of mouse intestinal RNA and the affection of radiation condition on its restorative effect, by measuring the survival of mouse intestinal crypt. The results showed (1) A decrease in the survival of mouse intestinal crypt began 6h after the irradiation, and the lowest survival rate appeared on the fourth day. (2) The survival of mouse intestinal crypt of the abdominal irradiated mice increased 21.4% at 6h after intestinal RNA injection as compared with that of the irradiated control group. (3) The dose modifying factor (DMF) of normal mouse intestinal RNA in the promotion of the recovery of the duodenum, jejunum and ileum of mice after whole body irradiation 1.17, 1.12 and 1.10 respectively. The above results suggest that mouse intestinal RNA can raise not only the survival of jejunum crypt of the mice of the same strain after abdominal irradiation but also the survival of crypt of the duodenum, jejunum and ileum of the mouse after whole body irradiation, which may be observed 6h after the irradiation