The synthesis of 1,3,4-thiadiazol-2-ylcyanamide sodium, a potentially useful anti-influenza agent and its [5-14C] and [UL-13C3] isotopomers

As an aid to the study of the metabolism and disposition of LY217896 in laboratory animals and humans, 14C-labeled material was prepared utilizing formic-[14C] acid as the starting material. Uniformly labeled LY217896-[13C] was also synthesized for use in metabolite identification. Formic acid, cyanogen bromide, and potassium cyanide which were > 99% isotopically enriched with 13C were utilized; once the appropriate starting materials were synthesized, the synthesis of the 13C and 14C-labeled materials were parallel. (author)