Published 1986 | Version v1
Journal article Metadata-only

Comparison of the pharmacokinetics of brain uptake of Technetium 99m labelled radiopharmaceuticals

Creators

Description

Several technetium 99m labelled compounds have recently been proposed for the evaluation of regional cerebral blood flow using SPECT. The kinetics of brain uptake of N-piperidinyl-ethyl-diaminodithiol (NEP-DADT) and its methyl derivative (met-NEP-DADT) and of propylene amine oxime (PnAO) and its derivative (HMPAO) was studied in dogs. The distribution was followed using a rotating gamma camera. A high and rapid uptake was found in brain tissue followed by rapid washout. Clear brain images were obtained. The results suggest that these tracers may be useful for brain imaging in humans

Abstract (French)

Plusieurs nouveaux composes marques au technetium 99m ont ete proposes recemment pour l'estimation du debit cerebral regional par tomographie a emission a photon unique (SPECT). On a compare la cinetique de fixation cerebrale du N-piperidinyl-ethyldiaminodithiol (NEP-DADT) et son derive methyle (met-NEP-DADT) chez le chien avec celle du propylene amine oxime (PnAO) et son derive (HMPAO), a l'aide d'une gamma camera tournante. On a constate une fixation precoce puis une decroissance assez rapide mais permettant aisement la realisation d'images de coupes du cerveau. Le choix du meilleur traceur necessitera d'autres etudes pour preciser lequel reflete plus precisement le debit cerebral regional chez l'homme

Additional details

Additional titles

Original title (French)
Pharmaco-cinetique comparee de radiopharmaceutiques marques au technetium 99m a tropisme cerebral

Publishing Information

Journal Title
J. Biophys. Biomec.
Journal Volume
10
Journal Issue
2,suppl
Series
J. Biophys. Biomec.
Journal Page Range
5-7
CODEN
JBNDD

Conference

Title
26. Nuclear medicine colloquium in French language.
Dates
18-20 Sep 1986.
Place
Deauville (France).

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
18085688
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL LOCALIZATION; BLOOD FLOW; BRAIN; COMPARATIVE EVALUATIONS; DITHIOLS; DOGS; DYNAMIC FUNCTION STUDIES; OXIMES; PIPERIDINES; RADIOPHARMACEUTICALS; SINGLE PHOTON ECT; TECHNETIUM 99
Descriptors DEC
AMINES; ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PYRIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; REAGENTS; TECHNETIUM ISOTOPES; THIOLS; TOMOGRAPHY; VERTEBRATES; YEARS LIVING RADIOISOTOPES