The cancer cell Adhesion resistome: mechanisms and its diagnostic and therapeutic potential

A large variety of extracellular and intracellular factors contribute to inherent and acquired cancer resistance mechanisms. Cell-extracellular matrix (ECM) interactions as part of multiprotein complexes called focal adhesions (FAs) are one of them. The several hundred signaling and adaptor proteins coalesced in FAs allow fundamental influence on numerous signaling networks dysfunctional in cancer cells that promote survival. My review presents the current knowledge on the Cancer Cell Adhesion Resistome and outlines their diagnostic and therapeutic potential. Own studies and studies by others. The Cancer Cell Adhesion Resistome offers numerous diagnostic and therapeutic opportunities for intervening in resistance, proliferation, migration/invasion, and metastasis. (author)