Study on 46Sc excretion-promoting action of DTPA-Ca and 811 in rats
Creators
- 1. Bethune (N.) Medical Univ., Changchun, JL (China). Dept. of Radiation Toxicololgy
Description
46Sc excretion-promoting effect of DTPA and 811 in rats was reported. The results showed that a change in the excretion route and an increase in the amount of excretion were observed, and some changes in the half-life of 46Sc-DTPA and 46Sc-811 took place acoordingly. Excretion of 46Sc from urine was substituted for the ordinary excretion route from the gastrointestinal tract. When compared with the control, both DTPA and 811 shortened the fast elimination phase of the biological half-life of 46Sc by 2.4 days (4.9 days for the control group), and the intermediate elimination phase by 2.77 and 4.9 days respectively (9.4 days for the control group). However, the slow elimination phase extended over 7.6 and 8.6 days respectively (18 days for the control group). Thus the authors believed that earlier intramuscular injection of DTPA and 811 will play an excellent role in promoting the exceretion of 46Sc in rats, and DTPA is better than 811
Additional details
Publishing Information
- Journal Title
- Journal of Norman Bethune University of Medical Sciences
- Journal Volume
- 14
- Journal Issue
- 6
- Series
- J. Norman Bethune Univ. Med. Sci.
- Journal Page Range
- 499-502
- ISSN
- 0253-3707
- CODEN
- PEIPO
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 21042923
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL HALF-LIFE; CHELATING AGENTS; DTPA; EXCRETION; RADIONUCLIDE KINETICS; RATS; SCANDIUM 46
- Descriptors DEC
- AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CLEARANCE; DAYS LIVING RADIOISOTOPES; DRUGS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MAMMALS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; SCANDIUM ISOTOPES; SECONDS LIVING RADIOISOTOPES; VERTEBRATES