The preparation, animal studies and preliminary clinical evaluation of 99mTc-ECD
Description
The 99mTc-ECD (ethyl cysteinate dimer) is a new brain perfusion imaging agent for SPECT. ECD has been synthesized recently. The 99mTcECD was prepared by ligand exchange reaction with 99mTc-GH (sodium glucoheptonate). The labelling yield was over 94%. The high brain uptake and retention of 99mTc-ECD was observed in monkey, and the tracer clearance was very rapid in blood. But biodistribution studies didn't display high brain uptake in rats with only 0.27% I.D/gram. at 5 min. postinjection. Initial human clinical studies were performed in 30 volunteers. The maximum 99mTc brain activity reached within 1 min. and remained near that level for next 10 min. The brain SPECT images were performed 20 min. after i.v. administration. High quality SPECT images of brain were obtained in all subjects. Preliminary results suggest that 99mTc-ECD is useful for clinical evaluation of rCBF
Additional details
Additional titles
- Subtitle (English)
- A new brain perfusion imaging agent
Publishing Information
- Journal Title
- Chinese Journal of Nuclear Medicine
- Journal Volume
- 9
- Journal Issue
- 4
- Series
- Chin. J. Nucl. Med.
- Journal Page Range
- 213-216
- ISSN
- 0253-9780
- CODEN
- CITCD
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 22018552
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BRAIN; CHEMICAL PREPARATION; CONTRAST MEDIA; CYSTEINE; ESTERS; IMAGES; LABELLED COMPOUNDS; LABELLING; TECHNETIUM 99
- Descriptors DEC
- AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIOISOTOPES; SYNTHESIS; TECHNETIUM ISOTOPES; THIOLS; YEARS LIVING RADIOISOTOPES