Published June 2009
| Version v1
Journal article
Oscillatory kinetics of gene expression: Protein conversion and slow mRNA transport
Creators
- 1. Chalmers University of Technology, Department of Applied Physics (Sweden)
Description
The negative feedback between mRNA and regulatory-protein production may result in oscillations in the kinetics of gene expression if the mRNA-protein interplay includes protein conversion. Using a mean-field kinetic model, we show that such oscillations can be amplified due to limitations of the mRNA transport between the nucleus and cytoplasm. This effect may be dramatic for the mRNA population in the nucleus
Additional details
Identifiers
Publishing Information
- Journal Title
- Journal of Experimental and Theoretical Physics
- Journal Volume
- 108
- Journal Issue
- 6
- Journal Page Range
- p. 1050-1053
- ISSN
- 1063-7761
- CODEN
- JTPHES
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 40107421
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- CYTOPLASM; FEEDBACK; GENES; KINETICS; MEAN-FIELD THEORY; MESSENGER-RNA; OSCILLATIONS; PROTEINS
- Descriptors DEC
- CELL CONSTITUENTS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RNA
Optional Information
- Copyright
- Copyright (c) 2009 Pleiades Publishing, Ltd.