The islet function examination of umbilical cord blood of newborn from cesarean section and vaginal delivery

Objective: To explore the difference of neonatal islet function between the vaginal delivery and cesarean section. Methods: Either 50 cases cesarean section or 50 cases vaginal delivery were randomly selected. The time of pregnancy was 39∼41 weeks. There were no obvious difference for birth weight and APgar score. The fetal umbilical cord insulin (INS), C peptide (C-P) and insulin antibody (ANS) for two groups were determined. The T lymphocytes antigen (CD4, CD8) was determined by Flow cytometric enzyme standard method. Results: The levels of CD4 antigens of umbilical cord blood lymphocytes of female baby from cesarean section and mixed antigen from CD4 and CD8 was significantly higher than that of in vaginal delivery group (P < 0.01), but the CD8 antigen was significantly lower than that of vaginal delivery group (P < 0.01); the ratio of CD4/CD8 of umbilical cord blood lymphocytes of female baby from cesarean section was significantly higher than the vaginal delivery group (P < 0.01); The level of CD4 and CD8 mixed antigen of umbilical cord blood lymphocytes of male baby from cesarean section was only significantly higher than a vaginal delivery group (P < 0.01). The levels of fetal umbilical cord blood insulin (INS) and C peptide (C-P) from cesarean sections were significantly lower than that of the vaginal delivery of production. The insulin antibodies (ANS) in two groups were negative. Conclusion: The cesarean section of the fetus could affect the fetal islet function and increase the risk of diabetes, and the immune dysfunction resulted by cesarean section may play a major role in these process. (authors)