Modification of the yield of gamma- and neutron-induced chromosome aberrations in human lymphocytes cultures at different stages of mitotic cycle. Cytogenetic effects at G1-stage

The impact of DNA of protein synthesis inhibitors (cycloheximide or hydroxyurea with 5-fluorodeoxyuridine - HU+FUrd, respectively) on the yield of chromosome aberration induced with gamma-rays (1 or 2 Gy) and neutrons (0.5 or 1 Gy) at G1-stage of mitotic cycle was studied in human lymphocytes. The both inhibitors were discovered to increase the effect of gamma-radiation at nearly all periods after irradiation during 5 hours. Conversely, the decrease in the level of chromosome aberrations was observed for neutrons after action of inhibitors at the same periods. 8 refs.; 2 figs