Published August 2019 | Version v1
Journal article Metadata-only

Methodological progress of 18F-labeled aromatic PET radiotracers

Creators

  • 1. College of Chemical and Biochemical Engineeringn, Zhejiang University, Hangzhou (China)
  • 2. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai (China)
  • 3. Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang Universit, School of Medicine, Institute Nuclear Medicine and Molecular Imaging fo Zhejiang University, Key Laboratory fo Medical Molecular Imaging fo Zhejiang Provincc, Hangzhou (China)

Description

PET serves as one of the most advanced imaging modalities, and its development depends on the improvement of radiotracers. Among numerous positron isotopes, 18F appears to be the best radionuclide candidate for PET radiotracers by virtue of its favorable physical characteristics. 18F-labeled aromatic radiotracers have been widely investigated by researchers due to its special metabolic stability. However, the development and application of 18F-labeled aromatic radiotracers have been limited due to lacking of radiochemical methods to obtain products with high selectivity, high radioactivity and high purity. This review focuses on the new labeling methods of 18F-labeled aromatic radiotracers from the aspects of electrophilic and nucleophilic substitution reactions. (authors)

Additional details

Identifiers

DOI
10.3760/cma.j.issn.2095-2848.2019.08.012;

Publishing Information

Journal Title
Chinese Journal of Nuclear Medicine and Molecular Imaging
Journal Volume
39
Journal Issue
8
Journal Page Range
p. 499-503
ISSN
2095-2848

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
55027220
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
AROMATICS; FLUORINE 18; IMPURITIES; LABELLING; POSITRON COMPUTED TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; REVIEWS; STABILITY; TRACER TECHNIQUES
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMISTRY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DOCUMENT TYPES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROCARBONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPES; TOMOGRAPHY

Optional Information

Notes
4 figs., 44 refs.; http://dx.doi.org/10.3760/cma.j.issn.2095-2848.2019.08.012