Published November 1989 | Version v1
Journal article Metadata-only

A one-pot radiosynthesis of [125I]iodoazido photoaffinity labels

Creators

  • 1. Johns Hopkins Medical Institutions, Baltimore, MD (USA). Div. of Nuclear Medicine
  • 2. National Inst. on Drug Abuse, Baltimore, MD (USA). Addiction Research Center

Description

A useful method for preparing radioiodinated photoaffinity labels from alkyl anilines which offer significant advantages over present methods is described. The one-pot synthesis gives good radiochemical yields (40-64%) of pure, high specific activity (350-1500 mCi/μmol) 124I labelled iodaryl azides while minimising manipulation of radioactive materials. Purification of the [125I]iodoazido photoaffinity labels is achieved by high performance liquid chromatography. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
27
Journal Issue
11
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1299-1305
ISSN
0362-4803
CODEN
JLCRD

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
22079850
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
AZIDO COMPOUNDS; CHEMICAL PREPARATION; DOPAMINE; IODINE 125; LABELLING; RADIOPHARMACEUTICALS; RECEPTORS
Descriptors DEC
AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; POLYPHENOLS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYMPATHOMIMETICS; SYNTHESIS

Optional Information

Contract/Grant/Project number
Grants USPHS CA-32845; NS-15080; MH-25951