Published June 1992 | Version v1
Report Restricted

Nuclear medicine and imaging research (quantitative studies in radiopharmaceutical science)

Creators

Description

This report describes three studies aimed at using radiolabeled pharmaceuticals to explore brain function and anatomy. The first section describes the chemical preparation of [F18]fluorinated benzamides (dopamine D-2 receptor tracers), [F18]fluorinated benzazepines (dopamine D-1 receptor tracers), and tissue distribution of [F18]-fluoxetine (serotonin reuptake site tracer). The second section relates pharmacological and behavioral studies of amphetamines. The third section reports on progress made with processing of brain images from CT, MRI and PET/SPECT with regards to brain metabolism of glucose during mental tasks

Availability note (English)

MF available from INIS under the Report Number; OSTI as DE92016969; NTIS; INIS; US Govt. Printing Office Dep.

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Additional details

Additional titles

Subtitle (English)
Progress report, January 1, 1992--December 31, 1992

Publishing Information

Imprint Pagination
22 p.
Report number
DOE/ER/60438--4

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
24001283
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Progress Report
Descriptors DEI
AMIDES; CEREBELLUM; CEREBRAL CORTEX; CEREBRUM; CHEMICAL PREPARATION; DOPAMINE; FLUORINE 18; LABELLING; LIQUID COLUMN CHROMATOGRAPHY; MAN; PROGRESS REPORT; RADIOPHARMACEUTICALS; RATS; RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHI; SYMPATHOLYTICS; TISSUE DISTRIBUTION
Descriptors DEC
AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY; DISTRIBUTION; DOCUMENT TYPES; DRUGS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SEPARATION PROCESSES; SYMPATHOMIMETICS; SYNTHESIS; VERTEBRATES

Optional Information

Contract/Grant/Project number
Contract FG02-86ER60438
Funding organization
USDOE, Washington, DC (United States).