Published 1975 | Version v1
Journal article Metadata-only

Effect of X-irradiation on vitamin B12 binding capacity to intrinsic factor

Creators

  • 1. Bhabha Atomic Research Centre, Bombay (India). Biochemistry and Food Technology Div.

Description

The effects of whole-body X-irradiation on vitamin bB12-protein complex formation in gastric juice after oral administration of [57Co]-B12 have been studied. Two proteins with B-12-binding activity have been isolated by gel filtration from gastric juice. 57Co-activity, recovered from B12-protein complex in gastric juice, is found to be about 30 percent less in the X-irradiated rat. In serum, vitamin B12 is mainly associated with alpha1-globulin. Radioactivity distribution in serum globulins after intraperitoneal injection of [57Co]-B12 was similar in control and X-irradiated rats. (author)

Additional details

Publishing Information

Journal Title
Environ. Physiol. Biochem.
Journal Volume
5
Series
Environ. Physiol. Biochem.
Journal Page Range
217-225

INIS

Country of Publication
Denmark
Country of Input or Organization
Denmark
INIS RN
7228263
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
COBALT 57; GASTROINTESTINAL TRACT; METABOLISM; ORAL ADMINISTRATION; RATS; VITAMIN B-12; WHOLE-BODY IRRADIATION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; COBALT ISOTOPES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; EXTERNAL IRRADIATION; INTERMEDIATE MASS NUCLEI; IRRADIATION; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; RODENTS; VERTEBRATES; VITAMIN B GROUP; VITAMINS