Published January 2012 | Version v1
Journal article Metadata-only

Labeling of Atenolol with Radioactive lodine-125 using N-Bromosuccinimide and Hydrogen peroxide as Oxidizing Agents

Creators

  • 1. Labeled Compounds Department. Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, Post No. 13759, Cairo (Egypt)

Description

An adopted method for the preparation of high radiochemical purify 125I -atenolol was investigated. Direct radioiodination of atenolol was carried out using N-bromo succinamide or hydrogen peroxide as an oxidizing agent. The reaction proceeds well within 30 min at room temperature of 25 ± 1 degree C and afforded a radiochemical yield up to 97 % as pure as '125I -atenolol. Different chromatographic techniques (electrophoresis, TLC and HPLC) were used to determine the radiochemical yield and purity of the labeled product

Additional details

Publishing Information

Journal Title
Arab Journal of Nuclear Sciences and Applications
Journal Volume
45
Journal Issue
1
Journal Page Range
p. 63-71
ISSN
1110-0451

INIS

Country of Publication
Egypt
Country of Input or Organization
Egypt
INIS RN
43018717
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ABSORPTION; AROMATICS; BLOOD PRESSURE; CHLORAMINES; DRUGS; ELECTROPHORESIS; HEART FAILURE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN PEROXIDE; IMIDAZOLES; IN VIVO; INDOLES; IODINE 125; LABELLING; MYOCARDIAL INFARCTION; NUCLEAR MEDICINE; OXIDIZERS; RADIOACTIVITY; RADIOCHEMICAL ANALYSIS; TEMPERATURE RANGE
Descriptors DEC
AMINES; AROMATICS; AZAARENES; AZOLES; BETA DECAY RADIOISOTOPES; CARDIOVASCULAR DISEASES; CHEMICAL ANALYSIS; CHROMATOGRAPHY; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOTOPES; LIQUID COLUMN CHROMATOGRAPHY; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXYGEN COMPOUNDS; PEROXIDES; PYRROLES; QUANTITATIVE CHEMICAL ANALYSIS; RADIOISOTOPES; SEPARATION PROCESSES; SORPTION; SYMPTOMS