Preparation and stability of rhenium [188Re] sulfide suspension with different particle size distributions

Two different dispersion methods were studied in order to obtain rhenium [188Re] sulfide suspension with different particle size distributions. The manufactured swirling device offers Suspension I with larger particles (55% > 5 μm, 19% > 10 μm). However, ultrasonication can only produce Suspension II with smaller particles (93% < 5 μm, 0.3% > 10 μm). Stability tests indicated that deposition appears after 6 and 15 minutes for Suspensions I and II, respectively. Radiochemical purity and particle size distribution did not change distinctively within 24 hours. So, both suspensions can be used in animal tests to find out the optimal particle size ranges for intra-articular injection. (author)