Published 1974 | Version v1
Book Metadata-only

Effect of mitomycin C on the genetic regulatory mechanism in the salivary gland chromosomes of drosophila melanogaster

Creators

  • 1. Calcutta Univ. (India). Dept. of Zoology

Description

Observation on the functional morphology and puffing pattern of the X-chromosome and a standard autosome, 3L from polytene chromosomes of late third instar larvae of Drosophila melanogaster after mitomycin C treatment, shows there is a selective effect on the male-X, only. Analysis of the replication and transcription patterns after 3H-TdR and 3H-UR autoradiography has also been done. The data reveals that mitomycin C, a known DNA inhibitor, alters the normal metabolic activities of the male-X specifically, as a result of the disturbance in the normal nucleoprotein metabolism. (author)

Additional details

Publishing Information

Publisher
Department of Atomic Energy.
Imprint Place
Bombay
Imprint Title
Proceedings of the symposium on control mechanisms in cellular processes, Bombay, 1 Feb-3 Feb 1973
Imprint Pagination
p. 375-383.

Conference

Title
Symposium on control mechanisms in cellular processes.
Dates
1 Feb 1973.
Place
Bombay, India.

INIS

Country of Publication
India
Country of Input or Organization
India
INIS RN
7257508
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AUTORADIOGRAPHY; CHROMOSOMES; DNA REPLICATION; DROSOPHILA; FEMALES; GENETIC EFFECTS; LABELLING; MALES; MITOMYCIN; SALIVARY GLANDS; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; URIDINE
Descriptors DEC
ANIMALS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ARTHROPODS; AZINES; BIOLOGICAL EFFECTS; BODY; DRUGS; FLIES; FRUIT FLIES; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; INSECTS; INVERTEBRATES; ISOTOPE APPLICATIONS; NUCLEIC ACID REPLICATION; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RIBOSIDES; URACILS

Optional Information

Notes
4 figs., 18 refs.