Study on the changes of serum IL-2, IL-6 and TNF-α levels in patients with chronic glomerulonephritis
- 1. The Hospital Affiliated of North Sichuan Medical College, Sichuan (China)
Description
Objective: To investigate the changes of serum IL-2, IL-6 and TNF-α levels in patients with chronic glomerulonephritis of various types and stages. Methods: Serum IL-2, IL-6 and TNF-α levels were measured with RIA in 71 patients with chronic glomerulonephritis and 36 controls. Results: 1) Serum levels of IL-6 and TNF-α were significantly higher in patients with chronic glomerulonephritis than those in controls (p<0.01) but serum IL-2 levels were significantly lower in the patients (p<0.01). 2)Serum IL-6 and TNF-α levels were positively correlated to BUN levels (p<0.01). 3)There were no significant differences of these cytokines levels among the different types of patients (i.e. general type n=18, nephrotic type n=33 and hypertensive type n=20). Conclusion: These cytokines participated in the pathogenesis of chronic glomerulonephritis. Monitoring the changes of their serum levels was helpful for the management of the disease
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 16
- Journal Issue
- 6
- Journal Page Range
- p. 348-350
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 35093076
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD SERUM; DIAGNOSIS; LYMPHOKINES; NEPHRITIS; PATHOLOGY; PATIENTS; RADIOIMMUNOASSAY; RESPONSE MODIFYING FACTORS
- Descriptors DEC
- BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; DISEASES; GROWTH FACTORS; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; MITOGENS; ORGANIC COMPOUNDS; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; TRACER TECHNIQUES; UROGENITAL SYSTEM DISEASES