Correlation between the expression of PTEN and anti-tumor activity of PARP inhibitor and radiation in cultured endometrial carcinoma cells
Creators
- 1. Tokyo University, Graduate School of Medicine and Faculty of Medicine, Tokyo (Japan)
Description
PTEN inactivation is the most frequent genetic aberration in endometrial cancer. One of the phosphatase-independent roles of PTEN is associated with homologous recombination (HR) in the nucleus. Poly (ADP-ribose) polymerase (PARP) plays key roles in the repair of DNA single-strand breaks, and a PARP inhibitor induces synthetic lethality in cancer cells with HR deficiency. Radiation also causes double strand break, which is repaired through HR. We examined the anti-tumor activity of PARP inhibitor and radiation on endometrial cancer cell lines with different PTEN status. Here we introduce this work, which was recently published (Aki Miyasaka, Katsutoshi Oda, Yuji Ikeda et al. Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cell line BMC Cancer 2014, 14: 179). (author)
Additional details
Publishing Information
- Journal Title
- Hoshasen Seibutsu Kenkyu
- Journal Volume
- 49
- Journal Issue
- 4
- Journal Page Range
- p. 410-417
- ISSN
- 0441-747X
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 47022851
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANTINEOPLASTIC DRUGS; CARCINOMAS; DNA REPAIR; ENZYME INHIBITORS; GENE MUTATIONS; GENE RECOMBINATION; GENE REGULATION; IRRADIATION; ONCOGENES; PHOSPHATASES; SENSITIVITY; STRAND BREAKS; TUMOR CELLS; UTERUS; VIABILITY
- Descriptors DEC
- ANIMAL CELLS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BODY; DISEASES; DNA DAMAGES; DRUGS; ENZYMES; ESTERASES; FEMALE GENITALS; GENES; HYDROLASES; MUTATIONS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; REPAIR