Published August 1993 | Version v1
Journal article Metadata-only

HPLC using physiological saline for the quality control of radiopharmaceuticals used in PET studies

Creators

  • 1. Tokyo Metropolitan Inst. of Gerontology (Japan). Positron Medical Center

Description

HPLC separation using a reverse phase column and physiological saline as an eluting solution is used for the quality control of radiopharmaceuticals used in PET studies. The compounds applied were 3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine, 2-[18F]fluoro-L-tyrosine, 2-[18F]fluoro-L-phenylalanine, 4-borono-2-[18F] fluoro-L-phenylalanine, L-[methyl-11C]methionine, 2-deoxy-2-[18F]fluoro-D-glucose, 5-[18F]-fluorouracil, and 2'-deoxy-5-[18F]fluorouridine. Human serum [11C]methylalbumin was also separated using a gel-filtration column and physiological saline. After the HPLC separation, the chemical and biological qualities of these compounds were of injectable grade. (Author)

Additional details

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
44
Journal Issue
8
Journal Page Range
p. 1119-1124.
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
24074176
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ALBUMINS; CARBON 11; FLUORINE 18; FLUOROURACILS; LABELLING; LIQUID COLUMN CHROMATOGRAPHY; PHENYLALANINE; POSITRON COMPUTED TOMOGRAPHY; QUALITY CONTROL; RADIOPHARMACEUTICALS; TYROSINE
Descriptors DEC
AMINO ACIDS; ANTIMETABOLITES; AROMATICS; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACIDS; CHROMATOGRAPHY; COMPUTERIZED TOMOGRAPHY; CONTROL; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PROTEINS; PYRIMIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; TOMOGRAPHY; URACILS