Brain blood flow in Alzheimer's disease measured with iodine-122 and positron emission tomography

It appears from this group of three patients that regional cerebral brain blood flow is closely coupled to regional metabolic rate in Alzheimer's disease. If this is the case with a larger series of patients, the rCBF measurement could be used to supplant the more expensive and time consuming 18FDG studies. The method should also have utility in measurement of flow-metabolism coupling in great variety of other brain disorders, or of flow alone, the latter especially in studies on normal subjects in which brain function is manipulated experimentally to measure flow changes during normal brain function. 1 fig., 1 tab