On postirradiation desensitization of the organism to adrenaline

In experiments with albino mongrel rats weighing 220-260 g a study was made of the affect of adrenaline on the cyclic nucleotide content of blood plasma at early times following 60 Co gamma-irradiation (75 Gy). The absence of the organism response to adrenaline is perhaps due to the development of post irradiation desensitization of β-adrenergic system and inability to induce cAMP formation in a cell. The data are submitted confirming the affect of levamisole on the cyclic nucleitide level. The level of cGMP decreased in thymocytes and increased in blood plasma after the administration of the drug to irradiated animals