Clinical study concerning upper urinary tract obstruction, 2

To establish a method of detecting divided renal function of the obstructed kidneys non-invasively, comparative studies on sup(99m)Tc-DMSA uptake (60 minutes after injection), I 131-hippuran renal uptake (1-2 minutes after injection) and divided creatinine clearance immediately after relief of urinary obstruction were made on 24 cases of obstructive uropathy. A close significant correlation was obtained between sup(99m)Tc-DMSA and I131-hippuran renal uptakes γ=0.8809, P<0.001). Also, a significant correlation was noted between sup(99m)Tc-DMSA renal uptake and divided creatinine clearance γ=0.7876, P<0.001), but the latter constantly gave lower values than the former. These observations led us to conclude that sup(99m)Tc-DMSA renal uptake is a reliable indicator of the renal plasma flow in the obstructed kidneys. Quantitative divided renal function of the obstructed kidneys can be estimated by the sup(99m)Tc-DMSA uptake method. (author)