Published July 1985
| Version v1
Journal article
Variation of OER with dose rate
- 1. George Washington Univ. Medical Center, Washington, DC
Description
The oxygen enhancement ratio (OER) has been measured as a function of dose rate from 276 Gy/hr to 0.89 Gy/hr for V-79 cells irradiated at 230C or 370C. As dose rate is decreased, the OER initially increases, from a value of 3.0 to a maximum value of 3.7 to 4.0, at a dose rate between 20 and 60 Gy/hr. The OER subsequently decreases with further dose rate reduction to a minimum value of 2.4 at the lowest dose rate. Similar experiments conducted with cells in nutrient deprived conditions exhibited a monotonic decrease in OER from 3.0 to 1.7 with dose rate reduction. These experimental findings can be understood in terms of the sublethal damage repair capability of cells under different pO2 and nutrient conditions
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Volume
- 11
- Journal Issue
- 7
- Series
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Page Range
- 1367-1373
- ISSN
- 0360-3016
- CODEN
- IOBPD
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17016321
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL REPAIR; CELL KILLING; COBALT 60; DOSE RATES; DOSE-RESPONSE RELATIONSHIPS; FIBROBLASTS; GAMMA RADIATION; HAMSTERS; HARD X RADIATION; OXYGEN ENHANCEMENT RATIO; RADIATION EFFECTS; SURVIVAL CURVES; TEMPERATURE DEPENDENCE
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL RECOVERY; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIATIONS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; VERTEBRATES; X RADIATION; YEARS LIVING RADIOISOTOPES