Hydrogen/deuterium isotope effects in water and aqueous solutions of organic molecules and proteins
Creators
- 1. CEMHTI, CNRS-Université d'Orléans, 45071 Orléans Cedex 2 (France)
- 2. CRMD, CNRS-Université d'Orléans, 45071 Orléans Cedex 2 (France)
- 3. UAI Física Aplicable CSIC - UPV/EHU, 48080 Bilbao (Spain)
- 4. Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom)
- 5. ISIS Facility, Rutherford Appleton Laboratory, Chilton, Didcot, Oxfordshire OX11 0QX (United Kingdom)
- 6. Institut de Minéralogie et Physique des Milieux Condenses, Universite Pierre et Marie Curie, CNRS-UMR 7590, 75005 Paris (France)
Description
Highlights: ► Hydrogen/deuterium substitution has significant effects in hydrogenous materials. ► The effects can involve structure, phase behavior and protein stability. ► The effects must be kept in mind in the interpretation of scattering experiments. ► The effects may be mitigated by an appropriate choice of experimental conditions. - Abstract: It is pointed out that hydrogen/deuterium substitution, frequently used in neutron scattering studies of the structure and dynamics of hydrogenous samples, can have significant effects on structure, phase behavior and protein stability. The effects must be kept in mind in the interpretation of such experiments. In suitable cases, these effects can be mitigated by an appropriate choice of experimental conditions
Availability note (English)
Available from http://dx.doi.org/10.1016/j.chemphys.2013.02.020Additional details
Identifiers
- DOI
- 10.1016/j.chemphys.2013.02.020;
- PII
- S0301-0104(13)00117-1;
Publishing Information
- Journal Title
- Chemical Physics
- Journal Volume
- 424
- Journal Page Range
- p. 62-69
- ISSN
- 0301-0104
- CODEN
- CMPHC2
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 45103725
- Subject category
- S74: ATOMIC AND MOLECULAR PHYSICS;
- Descriptors DEI
- AQUEOUS SOLUTIONS; DEUTERIUM; HYDROGEN; ISOTOPE EFFECTS; MOLECULES; NEUTRON DIFFRACTION; PROTEINS
- Descriptors DEC
- COHERENT SCATTERING; DIFFRACTION; DISPERSIONS; ELEMENTS; HOMOGENEOUS MIXTURES; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MIXTURES; NONMETALS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; SCATTERING; SOLUTIONS; STABLE ISOTOPES
Optional Information
- Copyright
- Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.