Published September 2018
| Version v1
Journal article
High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors
Creators
- 1. Department of Medical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg (Germany)
- 2. Department of Therapeutic Radiology, Yale University School of Medicine, New Haven (United States)
- 3. Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven (United States)
Description
Tumor hypoxia correlates with treatment failure in patients undergoing conventional radiation therapy. However, no published studies have investigated tumor hypoxia in patients undergoing stereotactic body radiation therapy (SBRT). We aimed to noninvasively quantify the tumor hypoxic volume (HV) in non-small cell lung cancer (NSCLC) tumors to elucidate the potential role of tumor vascular response and reoxygenation at high single doses.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.ijrobp.2018.05.032Additional details
Identifiers
- DOI
- 10.1016/j.ijrobp.2018.05.032;
- PII
- S0360301618308319;
Publishing Information
- Journal Title
- International Journal of Radiation Oncology, Biology and Physics
- Journal Volume
- 102
- Journal Issue
- 1
- Journal Page Range
- p. 174-183
- ISSN
- 0360-3016
- CODEN
- IOBPD3
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 54107156
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANOXIA; LUNGS; NEOPLASMS; PATIENTS; RADIOTHERAPY
- Descriptors DEC
- BODY; DISEASES; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY
Optional Information
- Copyright
- Copyright (c) 2018 Elsevier Inc. All rights reserved.