Age-dependent changes in expression of alpha1-adrenergic receptors in rat myocardium
Description
The expression of alpha1-adrenergic receptors within ventricular myocardium of rats ranging in age from 21 days of fetal life to 24 months after birth was measured from [125I] 2-(β hydroxy phenyl) ethylaminomethyl tetralone binding isotherms. No difference was observed in binding affinity between any of the age groups studied. The number of alpha1-adrenergic receptors was found to be 60-120% higher in membranes from fetal or immature rats up to 25 days of age when compared with adult animals. The increased expression of alpha1-adrenergic receptors in the developing heart relative to that observed in adult heart is consistent with the hypothesis that alpha1-adrenergic receptor stimulation may modulate protein synthesis and growth in mammalian myocardium
Additional details
Publishing Information
- Journal Title
- Biochem. Biophys. Res. Commun.
- Journal Volume
- 138
- Journal Issue
- 1
- Series
- Biochem. Biophys. Res. Commun.
- Journal Page Range
- 387-391
- ISSN
- 0006-291X
- CODEN
- BBRCA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18022775
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- AGE DEPENDENCE; BIOCHEMICAL REACTION KINETICS; EXPERIMENTAL DATA; IODINE 125; LABELLED COMPOUNDS; MYOCARDIUM; RATS; RECEPTORS; TRACER TECHNIQUES
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; DATA; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; HEART; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; MAMMALS; MUSCLES; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; REACTION KINETICS; RODENTS; VERTEBRATES