Published February 15, 1991 | Version v1
Journal article Metadata-only

Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle

Creators

  • 1. New York Medical College, Valhalla (United States)
  • 2. State Univ. of New York, Brooklyn (United States)
  • 3. Univ. of Texas, Dallas (United States)

Description

In the medullary segment of the thick ascending limb of the loop of Henle (mTALH), arachidonic acid (AA) is metabolized by a cytochrome P450-dependent monooxygenase to products that affect ion transport. The linkage between changes in ion transport and AA metabolism in isolated cells of the mTALH was examined. AA produced a concentration-dependent inhibition of 86Rb uptake-an effect that was prevented by selective blockade of cytochrome P450 monooxygenases. Inhibition by cytochrome 450 blockade of the effect of AA on 86Rb uptake could be circumvented by addition of the principal products of AA metabolism in the mTALH

Additional details

Publishing Information

Journal Title
Science (Washington, D.C.)
Journal Volume
251
Journal Issue
4995
Series
Science (Washington, D.C.).
Journal Page Range
799-802
ISSN
0036-8075
CODEN
SCIEA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
23039294
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ARACHIDONIC ACID; CATIONS; DOSE-RESPONSE RELATIONSHIPS; ENZYME ACTIVITY; INHIBITION; KIDNEYS; MEMBRANE TRANSPORT; METABOLISM; METABOLITES; OXIDOREDUCTASES; RABBITS; RUBIDIUM 86; TRACER TECHNIQUES
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CHARGED PARTICLES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; ENZYMES; INTERMEDIATE MASS NUCLEI; IONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; MONOCARBOXYLIC ACIDS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RUBIDIUM ISOTOPES; VERTEBRATES