Published August 2011 | Version v1
Journal article Metadata-only

The effect of local breast radiotherapy on circulating CD34+ cells

Creators

  • 1. Department of Medical Biophysics, University of Toronto (Canada)
  • 2. Ontario Cancer Institute, Toronto (Canada)
  • 3. Department of Radiation Oncology, University of Toronto (Canada)
  • 4. Department of Radiation Oncology, University Health Network, Toronto (Canada)
  • 5. Addenbrooke's Hospital, Cambridge (United Kingdom)
  • 6. Department of Pathology, University Health Network, Toronto (Canada)
  • 7. Division of Biostatistics, University Health Network, Toronto (Canada)
  • 8. Division of Medical Oncology and Hematology, University Health Network, Toronto (Canada)

Description

The number of circulating CD34+ (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2011.01.003

Additional details

Identifiers

DOI
10.1016/j.radonc.2011.01.003;
PII
S0167-8140(11)00017-X;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
100
Journal Issue
2
Journal Page Range
p. 304-307
ISSN
0167-8140
CODEN
RAONDT

INIS

Country of Publication
Ireland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
43064788
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CHEMOTHERAPY; HOMEOSTASIS; MAMMARY GLANDS; NEOPLASMS; PATIENTS; RADIOTHERAPY; STEM CELLS
Descriptors DEC
ANIMAL CELLS; BODY; DISEASES; GLANDS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; SOMATIC CELLS; THERAPY

Optional Information

Copyright
Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.