Published October 2017 | Version v1
Journal article Metadata-only

O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) uptake in insulinoma: first results from a xenograft mouse model and from human

Creators

  • 1. Université de Strasbourg, CNRS, IPHC, UMR 7178, F-67000, Strasbourg (France)
  • 2. Federation of Translational Medicine of Strasbourg (FMTS), Faculty of Medicine, Strasbourg University, Strasbourg (France)
  • 3. ICube, CNRS/UMR 7357, Strasbourg University, Strasbourg (France)
  • 4. Biophysics and Nuclear Medicine, Strasbourg University Hospitals, Strasbourg (France)
  • 5. EA7293, Vascular and Tissular Stress in Transplantation, Illkirch (France)
  • 6. Internal Medicine, Strasbourg University Hospitals, Strasbourg (France)
  • 7. Visceral Surgery and Transplantation, Strasbourg University Hospitals, Strasbourg (France)
  • 8. Diabetology, Strasbourg University Hospitals, Strasbourg (France)

Description

Herein we have evaluated the uptake of O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) in insulinoma in comparison with those of 6-18F-fluoro-3,4-dihydroxy-l-phenylalanine (18F-FDOPA) providing first data from both murine xenograft model and one patient with proved endogenous hyperinsulinemic hypoglycemia.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nucmedbio.2017.07.005

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2017.07.005;
PII
S0969805117302123;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
53
Journal Page Range
p. 21-28
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
51078425
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
FLUORINE 18; MICE; PATIENTS; PHENYLALANINE; TYROSINE
Descriptors DEC
AMINO ACIDS; ANIMALS; AROMATICS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROCARBONS; HYDROXY ACIDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; RODENTS; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2017 Elsevier Inc. All rights reserved.