Published 1983 | Version v1
Book Metadata-only

Mechanism for nucleotide selection associated with the pyrophosphate exchange activity of DNA polymerases

Creators

  • 1. Universite Libre de Brussels, Belgium

Description

The nucleotide incorporation reaction carried out by DNA polymerases can be dissected into several theoretically possible steps. Two of the reactions differ only in the source of the PPi; endogenous PPi being used in one while, exogenous PPi is used in the other. These steps have been postulated to release free dNMP and PPi from the DNA/sub n/.dNMP.PPi intermediate in what could be a proofreading reaction occurring preferentially with non-complementary nucleosides. In this paper we consider the possibility that this putative DNA.dNMP.PPi intermediate is indeed subject to proofreading reactions. 24 references, 3 figures, 1 table

Additional details

Publishing Information

Publisher
Alan R. Liss, Inc.
Imprint Place
New York, NY (USA)
Imprint Title
Cellular responses to DNA damage
Journal Page Range
p. 489-499.

Conference

Title
UCLA symposia on molecular and cellular biology.
Dates
10-15 Apr 1983.
Place
Keystone, CO (USA).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
16038333
Subject category
S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ACCURACY; BACTERIOPHAGES; CATALYSIS; DNA POLYMERASES; DNA REPLICATION; ENZYME INHIBITORS; ENZYMES; METABOLISM; PHOSPHORUS 32; TRACER TECHNIQUES
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MICROORGANISMS; NUCLEI; NUCLEIC ACID REPLICATION; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PARASITES; PHOSPHORUS ISOTOPES; POLYMERASES; RADIOISOTOPES; VIRUSES