Published 2004
| Version v1
Miscellaneous
Alkaloids from cythostemma argenteum and evaluation of their cytotoxic activities against four types of breast cancel cell-lines
Creators
- 1. Malaysian Inst. for Nuclear Technology Research MINT, Bangi (Malaysia). Medical Technology Div.
- 2. University of Bradford, Bradford (United Kingdom). School of Pharmacy
Description
Two isoquinoline alkaloids, liriodenine (1) and discretamine (2), were isolated from the root and stembark of Cyathostemma argenteum (BI) Sinclair, respectively. Their structures were elucidated using spectroscopic techniques. Of the two only liriodenine (1) showed significant cytotoxicity on all four type of human breast cancer cell-lines used. The mean IC50 for liriodenine against the MCF-7, MCF-7/ADR, MDA-B435 and MT-1 breast cancer cell -lines were 4.3, 4.6, 4.5 and 5.0 μg/ml, respectively. Discretamine was found to be non-cytotoxic (IC50 > I 00 μg/mI). (Author)
Additional details
Publishing Information
- Publisher
- Malaysian Inst. for Nuclear Technology Research MINT
- Imprint Place
- Bangi (Malaysia)
- Imprint Title
- Proceedings of the MINT R and D Seminar 2004: Innovation through excellence in R and D, Seminar B
- Imprint Pagination
- 404 p.
- Journal Page Range
- p. 264-269
Conference
- Title
- Seminar MINT R and D 2004
- Dates
- 12-15 Jul 2004
- Place
- Bangi (Malaysia)
INIS
- Country of Publication
- Malaysia
- Country of Input or Organization
- Malaysia
- INIS RN
- 35105106
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference, Non-conventional Literature
- Descriptors DEI
- ANIMAL CELLS; CYTOLOGY; HERBS; MAMMARY GLANDS; NEOPLASMS; ROOTS; STEM CELLS; TOXICITY
- Descriptors DEC
- ANIMAL CELLS; BIOLOGY; BODY; DISEASES; GLANDS; ORGANS; PLANTS; SOMATIC CELLS