In vivo tumor localization and biodistribution in the human tumor xenografts models of an anti-CD71 mouse/human chimeric antibody
Creators
- 1. Jianghan Univ., Wuhan (China). College of Medicine and Life Science
- 2. Tongji Medical College of Huazhong Univ. of Science and Technology, Wuhan (China). Inst. of Immunology
- 3. Union Hospital of Tongji Medical College of Huazhong Univ. of Science and Technology, Wuhan (China). Dept. of Nuclear Medicine
Description
Objective: In order to investigate the tumor localization and biodistribution of the anti-CD71 mouse/human chimeric antibody (D2C). Methods: The tumor localization and biodistribution of the chimeric antibody (D2C) were observed by labeling the chimeric Ab with radioiodine (131I) and injecting it into nude mice (Balb/c nu/nu) transplanted with human hepatocellular carcinoma cells (SMMC-7721). Results: The labeled chimeric Ab (D2C), with intraperitoneal as well as tumor regional administration, was significantly localized in the tumor and the location of the tumor was successfully visualized by SPECT. The in vivo D2C Ab's biodistribution of organs and tissues showed that non-specific binding in the tumor regional administration was lower than those in the intraperitoneal. Conclusion: The human/mouse chimeric antibody (D2C) can exert in specific tumor localization in vivo and can be utilized for radio-immunoimaging
Additional details
Publishing Information
- Journal Title
- Asian Journal of Nuclear Medicine
- Journal Volume
- 2
- Journal Issue
- 1
- Journal Page Range
- p. 29-32
- ISSN
- 1607-680X
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 36021182
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANTIBODIES; BIOLOGICAL LOCALIZATION; CHIMERAS; DIAGNOSIS; IN VIVO; IODINE 131; LABELLING; LIVER; MAN; MICE; NEOPLASMS; RADIOPHARMACEUTICALS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SODIUM IODIDES; TISSUE DISTRIBUTION; TUMOR CELLS
- Descriptors DEC
- ALKALI METAL COMPOUNDS; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DISTRIBUTION; DRUGS; EMISSION COMPUTED TOMOGRAPHY; GLANDS; HALIDES; HALOGEN COMPOUNDS; INORGANIC PHOSPHORS; INTERMEDIATE MASS NUCLEI; IODIDES; IODINE COMPOUNDS; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MOSAICISM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PHOSPHORS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SODIUM COMPOUNDS; TOMOGRAPHY; VERTEBRATES