Studies on hepatobiliary functional scintigraphy

111 patients with liver cell or bile duct diseases underwent a liver function examination using 99mTc-HIDA, specifically with the bolus-injection technique followed by sequential scanning with computer-supported image data processing. A liver parenchyma presentation was achieved in 107 cases well or very well, except with high bilirubin values. With this it was also possible to make a size determination of the organ as in colloid scanning. Liver metastases must have attained a certain minimal size for a 'negative presentation'. Hobnail liver or adiposis hepatica accumulates the radiopharmaceutical very unevenly. In the bile ducts, if at all, then only the hepatocholedochus and the left bile duct could be satisfactorily presented (fresh icterus). In 78 cases a clear detection of intestinal activity was achieved, in 63 cases the detection of the gall bladder, the rest of the cases dealt with cholecystectomised patients or patients with cholecystitis, bile duct obstructions, etc. The described examination correlated with its results the best with the bilirubin values, in the second case also with the transaminases SGOT and SGPT, although in contrast to HBFS it deals with a measure for no longer functional hepatocytes. A not so good correlation exists between the alkaline phosphatase and LDH. Conclusively it can be said, that the ascertained curve parameters from the whole body and liver parenchyma do not stand in contradiction to the relevant blood lab values. However, a particular diagnosis can not be drawn from the curve parameters alone. (TRV)