The Radiosensitivity of tamoxifen to human glioma cells SHG-44
Creators
- 1. School of Radiation Medicine and Public Health, Medical College of Suzhou Univ., Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection Jiangsu, Suzhou (China)
Description
Objective: To study the radiosensitivity of tamoxifen to the human glioma cell lines SHG-44. Methods: 3H-TdR incorporation assay was used to detect DNA synthesis in glioma cells SHG-44, which were exposed to 60Co γ-irradiation with 0,1,3,5,7,9 Gy. When T lymphocyte and B lymphocyte from human peripheral blood were stimulated by phyto- agglutinin (PHA) and lipopolysaccharide (LPS), the effect of tamoxifen on proliferation of T lymphocyte and B lymphocyte was assessed by the same method. Results: Tamoxifen shifted the radiation dose-response curve to the left, with the decrease of D0 values. Tamoxifen(2-8 μmol/L) shows no significant inhibitory effects on proliferation of T lymphocyte and B lymphocyte, and there was no significant difference between TAM group and the control group (P>0.05). Conclusion: Tamoxifen could increase radiosensitivity of glioma cells SHG-44 to γ-irradiation, and it had no effect on the proliferation of T lymphocyte and B lymphocyte at the concentration of 2-8 μmol/L. (authors)
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Radiological Health
- Journal Volume
- 18
- Journal Issue
- 1
- Journal Page Range
- p. 15-16
- ISSN
- 1004-714X
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 41105404
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- AGGLUTININS; COBALT 60; DETECTION; DNA; GAMMA RADIATION; GLIOMAS; HUMAN POPULATIONS; IRRADIATION; LABELLED COMPOUNDS; LYMPHOCYTES; POLYSACCHARIDES; PROLIFERATION; RADIATION DOSES; RADIOSENSITIVITY; RADIOSENSITIZERS; STIMULATION; SYNTHESIS; TAMOXIFEN; THYMIDINE; TRITIUM
- Descriptors DEC
- ANIMAL CELLS; ANTIBODIES; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOHYDRATES; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; DISEASES; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKOCYTES; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEI; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; POPULATIONS; PYRIMIDINES; RADIATIONS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RIBOSIDES; SACCHARIDES; SENSITIVITY; SOMATIC CELLS; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- 1 fig., 3 tabs., 6 refs.