Published June 1975 | Version v1
Journal article Metadata-only

A comparative study of sup(99m)Tc-polyphosphate and sup(99m)Tc-diphosphonate

Creators

  • 1. Deutsche Klinik fuer Diagnostik, Wiesbaden (F.R. Germany). Sektion Nuklearmedizin

Description

sup(99m)Tc-labelled phosphates are the bone seeking agents of choice. The comparison of sup(99m)Tc-polyphosphate (Poly-P) and sup(99m)Tc-ethane-1-hydroxy-1,1-diphosphonate (EHDP) shows a better in vitro stability of the latter during the first two hours after preparation. The blood clearance of EHDP is superior to Poly-P resulting in reduced background activity at scanning time. Renal excretion over a 4-hour period of urine sampling showed no significant differences between both substances. Blood activity is independent of diuresis. (orig.)

Abstract (German)

Der Vergleich des knochenaffinen 99mTc-rnarkierten EHDP und des Poly-P zeigt hinsichtlich der Blut-Clearance und der Qualität der Kamerabilder bzw. Farbszintigramme eine deutliche Überlegenheit des EHDP. In vitro ist das EHDP bis 120 Minuten nach Präparation stabiler als das Poly-P. In vivo werden die P-O-P-Bindungen des Poly-P durch Phosphatasen aufgespalten, wohingegen die P-C-P-Bindung des EHDP weitgehend stabil ist. Die renale Ausscheidung beider Substanzen über 4 Stunden läßt keine sicheren Differenzen erkennen. Die Blutradioaktivität zeigt bei beiden Substanzen keine Beziehung zu den Diureseverhältnissen.

Additional details

Additional titles

Original title (German)
Technetiumpolyphosphat und Technetiumdiphosphonat. Eine vergleichende Untersuchung

Identifiers

DOI
10.1055/s-0038-1624889;

Publishing Information

Journal Title
Nuklearmedizin
Journal Volume
14
Journal Issue
02
Series
Nucl.-Med.
Journal Page Range
83-90
ISSN
0029-5566

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
6209789
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S60: APPLIED LIFE SCIENCES;
Descriptors DEI
BLOOD-PLASMA CLEARANCE; BONE SEEKERS; IN VITRO; IN VIVO; ISOMERIC NUCLEI; NUCLEAR MEDICINE; ORGANOPHOSPHINIC ACIDS; PATIENTS; PERTECHNETATES; PHOSPHATASES; PHOSPHATES; PHOSPHINIC ACID ESTERS; RADIOPHARMACEUTICALS; RENAL CLEARANCE; SCINTISCANNING; TECHNETIUM 99
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CLEARANCE; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; ENZYMES; ESTERASES; ESTERS; EXCRETION; HOURS LIVING RADIOISOTOPES; HYDROLASES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM COMPOUNDS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPOUNDS; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
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