Tungstosulfonic acid-catalyzed green synthesis and bioassay of α-aminophosphonates

An eco-friendly green synthetic procedure was accomplished through the one-pot three-component synthesis of α-aminophosphonates having –CF₃ moiety in good to excellent yields, under ultrasonication and solvent-free conditions in the presence of tungstosulfonic acid as an efficient, reusable, heterogeneous solid acid catalyst. All the title compounds were evaluated for their antioxidant activity using DPPH, H₂O₂ methods and antimicrobial activity by disc diffusion method. The bio-activity revealed that all the title compounds showed significant antioxidant and antimicrobial activities. Graphical abstract:

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