The clinical acceptability of short versus long duration acquisitions for head and neck cancer using long-axial field-of-view PET/CT. A retrospective evaluation

To evaluate the utility of long duration (10 min) acquisitions compared to standard 4 min scans in the evaluation of head and neck cancer (HNC) using a long-axial field-of-view (LAFOV) system in 2-[18F]FDG PET/CT. HNC patients undergoing LAFOV PET/CT were included retrospectively according to a predefined sample size calculation. For each acquisition, FDG avid lymph nodes (LN) which were highly probable or equivocal for malignancy were identified by two board certified nuclear medicine physicians in consensus. The aim of this study was to establish the clinical acceptability of short-duration (4 min, C${}_{40\%}$) acquisitions compared to full-count (10 min, C${}_{100\%}$) in terms of the detection of LN metastases in HNC. Secondary endpoints were the positive predictive value for LN status (PPV) and comparison of SUV${}_{max}$ at C${}_{40\%}$ and C${}_{100\%}$. Histology reports or confirmatory imaging were the reference standard. A total of 1218 records were screened and target recruitment was met with n = 64 HNC patients undergoing LAFOV. Median age was 65 years (IQR: 59-73). At C${}_{40\%}$, a total of 387 lesions were detected (highly probable LN n = 274 and equivocal n = 113. The total number of lesions detected at C${}_{100\%}$ acquisition was 439, of them 291 (66%) highly probable LN and 148 (34%) equivocal. Detection rate between the two acquisitions did not demonstrate any significant differences (Pearson's Chi-Square test, p = 0.792). Sensitivity, specificity, PPV, NPV and accuracy for C${}_{40\%}$ were 83%, 44%, 55%, 76% and 36%, whilst for C${}_{100\%}$ were 85%, 56%, 55%, 85% and 43%, respectively. The improved accuracy reached borderline significance (p = 0.057). At the ROC analysis, lower SUVmax was identified for C${}_{100\%}$ (3.5) compared to C${}_{40\%}$ (4.5). In terms of LN detection, C${}_{40\%}$ acquisitions showed no significant difference compared to the C${}_{100\%}$ acquisitions. There was some improvement for lesions detection at C${}_{100\%}$, with a small increment in accuracy reaching borderline significance, suggestive that the higher sensitivity afforded by LAFOV might translate to improved clinical performance in some patients.