Published July 1994 | Version v1
Journal article Metadata-only

Clinical evaluation of efficacy of romurtide for radiation-induced leukopenia in cancer patients

Creators

  • 1. Kagoshima Univ. (Japan). Faculty of Medicine

Description

Romurtide, a derivative of muramyl dipeptide, is known to augment the number of WBC via potentiation of colony stimulating factor (CSF) production by macrophage. Thirty five cancer patients with radiation induced leukopenia (≤3,000/mm3) were subcutaneously given 200 μg of romurtide for 10 consecutive days. The recovery of WBC was observed in 26/34 (76%) patients. Increase of neutrophils in number was prominent. Radiotherapy was completed in 34 of the 35 patients (97%). The side effects were acceptable. Thus romurtide is useful to treat patients with radiation induced leukopenia. (author)

Additional details

Publishing Information

Journal Title
Rinsho Hoshasen
Journal Volume
39
Journal Issue
7
Journal Page Range
p. 807-812.
ISSN
0009-9252
CODEN
RHOSAM

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
25072674
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BLOOD PLATELETS; CARCINOMAS; CHEST; ESOPHAGUS; EXTERNAL IRRADIATION; LEUKOPENIA; METASTASES; NEUTROPHILS; OLIGOSACCHARIDES; PATIENTS; PELVIS; PEPTIDES; RADIATION DOSES; RADIOTHERAPY
Descriptors DEC
ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY AREAS; BODY FLUIDS; CARBOHYDRATES; DIGESTIVE SYSTEM; DISEASES; HEMIC DISEASES; IMMUNE SYSTEM DISEASES; IRRADIATION; LEUKOCYTES; MAMMALS; MAN; MATERIALS; MEDICINE; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PRIMATES; PROTEINS; SACCHARIDES; SYMPTOMS; THERAPY; VERTEBRATES