Penetration enhancer: monoethylether of diethylene glycol
- 1. Dept. of Environmental Chemistry and Technology, Fa. of Chemical Technology, Slovak Technical University, 81237 Bratislava (Slovakia)
- 2. Inst. of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava (Slovakia)
- 3. Welsh School of Pharmacy, Cardiff (United Kingdom)
- 4. Inst. of Pharmaceutical and Biological Sciences, Univ. of Claude Bernard, Lyon (France)
Description
The monoethylether of diethylene glycol (Transcutol), an excellent solubilising agent, has been suggested as a penetration enhancer compatible with trans-dermal drug delivery systems. Using the abdominal skin of 5 day old rats and Franz-type diffusion cells the following topics were studied in this contribution: (1) Flux of Transcutol, labelled with [Ethyl-14C]-ether, across an intact skin model, (2) Changes in properties of the skin barrier after stripping with adhesive tape, and (3) Changes in flux of Transcutol when mixed with different co-solvents. The flux from pure solvent in donor compartment reached around 50 μg cm-2 hr-1 across the intact skin horny layer, whilst after 12 strips the flux increased about 200 times. In the presence of propylene glycol dipelargonate, the flux over 2 mg cm-2 hr-1 across non stripped skin was achieved. (authors)
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Additional details
Additional titles
- Original title (English)
- 51. Zjazd chemickych spolocnosti: Zbornik prispevkov, Diel: Program, 1, 2, 3, 4 Molekulove modely (Workshop)
Publishing Information
- Publisher
- Slovak Technical University Publishing House
- Imprint Place
- Bratislava (Slovakia)
- Imprint Title
- 51. Meeting of the Chemical Societies: Almanac of Contributions, Vol. Program, 1, 2, 3, 4 Molecular Models (Workshop)
- Imprint Pagination
- 986 p.
- Journal Page Range
- p. 1, v.2
- Report number
- INIS-SK--00-09
Conference
- Title
- 51. Meeting of the Chemical Societies
- Original Conference Title
- 51. Zjazd chemickych spolocnosti
- Acronym
- ZCHS'99
- Dates
- 6-9 Sep 1999
- Place
- Nitra (Slovakia)
INIS
- Country of Publication
- Slovakia
- Country of Input or Organization
- Slovakia
- INIS RN
- 31029755
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference, Numerical Data
- Descriptors DEI
- ANIMAL TISSUES; CARBON 14; CARBON 14 COMPOUNDS; CONSUMER PRODUCTS; EXPERIMENTAL DATA; LABELLED COMPOUNDS; LABELLED POOL TECHNIQUES; LABELLING; NUCLEAR CHEMISTRY; QUANTITATIVE CHEMICAL ANALYSIS; RADIOCHEMICAL ANALYSIS; RADIOCHEMISTRY; RADIOMETRIC ANALYSIS; RADIONUCLIDE KINETICS; RADIONUCLIDE MIGRATION; RATS; SKIN; SKIN ABSORPTION; TISSUE DISTRIBUTION; UPTAKE
- Descriptors DEC
- ABSORPTION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBON COMPOUNDS; CARBON ISOTOPES; CHEMICAL ANALYSIS; CHEMISTRY; DATA; DISTRIBUTION; ENVIRONMENTAL TRANSPORT; EVEN-EVEN NUCLEI; INFORMATION; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MASS TRANSFER; NUCLEI; NUMERICAL DATA; ORGANS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOISOTOPES; RODENTS; SORPTION; TRACER TECHNIQUES; UPTAKE; VERTEBRATES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- Pages L-P7 Imprint:51. Zjazd chemickych spolocnosti: Zbornik prispevkov, Diel: Program, 1, 2, 3, 4 Molekulove modely (Workshop)