Published August 2004 | Version v1
Journal article

Changes of serum leptin, adiponection and insulin levels in females with simple obesity

  • 1. Qingdao Municipal Hospital, Qingdao (China). Center of RIA

Description

Objective: To study the changes of serum leptin, insulin and adiponectin levels and their relationship with BMI in females with simple obesity. Methods: Serum leptin, adiponectin and insulin levels were measured with RIA in 48 pre-obese females (BMI=23-24.9 kg/m2), 40 females with simple obesity, (BMI≥25 kg/m2) and 42 female controls (BMI 18-22.9 kg/m2). Correlations among these variables were studied. Results: Serum leptin, insulin levels were significantly higher and serum adiponectin levels were significantly lower in both the pre-obese and obese females than those in controls. Serum leptin, insulin levels were positively correlated to BMI; Serum adiponectin levels were negatively correlated to BMI. Conclusion: Within normal range of BMI, the leptin-insulin feedback mechanism provided satisfactory self-regulation. However, with excessive BMI, this dynamic equilibrium would be disrupted. The defective equilibrium, together with the abnormal low adiponectin level, would predispose to the development of diabetes mellitus. (authors)

Additional details

Publishing Information

Journal Title
Journal of Radioimmunology
Journal Volume
17
Journal Issue
4
Journal Page Range
p. 258-261
ISSN
1008-9810

Optional Information

Notes
2 tabs., 7 refs.