Changes of serum leptin, adiponection and insulin levels in females with simple obesity
Creators
- 1. Qingdao Municipal Hospital, Qingdao (China). Center of RIA
Description
Objective: To study the changes of serum leptin, insulin and adiponectin levels and their relationship with BMI in females with simple obesity. Methods: Serum leptin, adiponectin and insulin levels were measured with RIA in 48 pre-obese females (BMI=23-24.9 kg/m2), 40 females with simple obesity, (BMI≥25 kg/m2) and 42 female controls (BMI 18-22.9 kg/m2). Correlations among these variables were studied. Results: Serum leptin, insulin levels were significantly higher and serum adiponectin levels were significantly lower in both the pre-obese and obese females than those in controls. Serum leptin, insulin levels were positively correlated to BMI; Serum adiponectin levels were negatively correlated to BMI. Conclusion: Within normal range of BMI, the leptin-insulin feedback mechanism provided satisfactory self-regulation. However, with excessive BMI, this dynamic equilibrium would be disrupted. The defective equilibrium, together with the abnormal low adiponectin level, would predispose to the development of diabetes mellitus. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 17
- Journal Issue
- 4
- Journal Page Range
- p. 258-261
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 36114253
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Quality check status
- Yes
- Descriptors DEI
- BLOOD SERUM; CERULOPLASMIN; DATA COVARIANCES; DIAGNOSIS; INSULIN; LEPTIN; METABOLIC DISEASES; PATHOGENESIS; RADIOIMMUNOASSAY; REGRESSION ANALYSIS; STATISTICS; WOMEN;
- Descriptors DEC
- ANIMALS; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; COMPLEXES; COPPER COMPLEXES; DIAGNOSTIC TECHNIQUES; DISEASES; FEMALES; GLOBULINS; GLOBULINS-ALPHA; HORMONES; IMMUNOASSAY; ISOTOPE APPLICATIONS; MAMMALS; MAN; MATERIALS; MATHEMATICS; METALLOPROTEINS; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PRIMATES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; STATISTICS; TRACER TECHNIQUES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES;
Optional Information
- Notes
- 2 tabs., 7 refs.